Planta Med 2010; 76 - P102
DOI: 10.1055/s-0030-1264400

Formulation and stability test of BJ adaptogen tablets for cancer treatment

M Suthanurak 1, I Sakpakdeejaroen 2, R Rattarom 3, A Itharat 4
  • 1Student in Master of Health Science Program, Faculty of Medicine, Thammasart University, Klongluang, 12120 pathumtani, Thailand
  • 2Division of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasart University, Klong luang, 12120 pathumtani, Thailand
  • 3Department of Pharmacognosy, Faculty of Pharmaceutical Science, Mahasarakam University, Meuang, – Mahasarakan, Thailand
  • 4Division of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasart University, Rungsit Campus, Division of Applied Thai Traditional Medicine, Pahonyothin road, Klong Luang, 12120 Pathumtani, Thailand

BJ adaptogen is a Thai Traditional medicine preparation, used for balanced health and cancer treatment by Thai folk doctors. This preparation is composed of five plants; Piper longum, Piper samentosum, Piper interuptum, Plumbago indica and Zingiber officinale. Its ethanolic extract exhibited high cytotoxic activity against lung cancer cells or COR-L23 (IC50=19.80µg/ml) by SRB assay [1,2]. Its main compound was determined as piperine. In this investigation, we formulated a BJ adaptogen extract tablet and tested its stability under accelerated condition (45°C, 75%RH, 4 months) by determination of piperine content in the tablets by HPLC. A wet granulation method was used in developing the tablets. The suitable excipients were lactose, starch, Explotab® and magnesium stearate. The physical properties of tablets were evaluated following the USP25 requirements. The results of stability testing found that content of piperine from BJ adaptogen extract tablets was reduced by 10% within 4 months.

Acknowledgements: Faculty of medicine, Thammasart University for financial support

References: 1. Itharat, A. et al. (2004)J. of Ethnopharmacology: 90:33–38.

2. Skehan P et al.(1990)J Natl Cancer Inst 1990: 82(13): 1107–12.