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DOI: 10.1055/s-0030-1264400
Formulation and stability test of BJ adaptogen tablets for cancer treatment
BJ adaptogen is a Thai Traditional medicine preparation, used for balanced health and cancer treatment by Thai folk doctors. This preparation is composed of five plants; Piper longum, Piper samentosum, Piper interuptum, Plumbago indica and Zingiber officinale. Its ethanolic extract exhibited high cytotoxic activity against lung cancer cells or COR-L23 (IC50=19.80µg/ml) by SRB assay [1,2]. Its main compound was determined as piperine. In this investigation, we formulated a BJ adaptogen extract tablet and tested its stability under accelerated condition (45°C, 75%RH, 4 months) by determination of piperine content in the tablets by HPLC. A wet granulation method was used in developing the tablets. The suitable excipients were lactose, starch, Explotab® and magnesium stearate. The physical properties of tablets were evaluated following the USP25 requirements. The results of stability testing found that content of piperine from BJ adaptogen extract tablets was reduced by 10% within 4 months.
Acknowledgements: Faculty of medicine, Thammasart University for financial support
References: 1. Itharat, A. et al. (2004)J. of Ethnopharmacology: 90:33–38.
2. Skehan P et al.(1990)J Natl Cancer Inst 1990: 82(13): 1107–12.