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Synfacts 2011(10): 1039-1039  
DOI: 10.1055/s-0030-1261144
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Liphagal

Contributor(s): Steven V. Ley, Sean Newton
J. J. Day, R. M. McFadden, S. C. Virgil, H. Kolding, J. L. Alleva, B. M. Stoltz*
California Institute of Technology, Pasadena, USA
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Publikationsdatum:
20. September 2011 (online)

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Significance

(+)-Liphagal was isolated in 2006 from the Caribbean sponge Aka coralliphaga and belongs to a family of phosphatidylinositol 3-kinase (PI3K) inhibitors. Structurally, (+)-liphagal consists of an unprecedented [6-7-5-6] tetracyclic motif. Herein, the first catalytic enantioselective approach is reported.