Cu-Catalyzed Asymmetric Propargylation of Ketones

K. R. Fandrick; D. R. Fandrick; J. T. Reeves; J. Gao; S. L. Ma; W. J. Li; H. Lee; N. Grinberg; B. Lu; C. H. Senanayake

doi:10.1055/s-0030-1261065

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Synfacts 2011(10): 1100-1100
DOI: 10.1055/s-0030-1261065

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Cu-Catalyzed Asymmetric Propargylation of Ketones

Contributor(s): Hisashi Yamamoto, Jiajing Tan
K. R. Fandrick*, D. R. Fandrick, J. T. Reeves, J. Gao, S. L. Ma, W. J. Li, H. Lee, N. Grinberg, B. Lu, C. H. Senanayake
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA

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Publication History

Publication Date:
20 September 2011 (online)

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Significance

A simple Cu-BINAP catalyst system was developed which successfully promoted the highly enantioselective propargylation of ketones. The corresponding homopropargylic alcohols were obtained in good to high yields and enantioselectivities.