Asymmetric Rhodium-Catalyzed Synthesis of Tertiary Propargyl Alcohols
T. Ohshima*, T. Kawabata, Y. Takeuchi, T. Kakinuma, T. Iwasaki, T. Yonezawa, H. Murakami, H. Nishiyama, K. Mashiama*
Kyushu University, Fukuoka, Osaka University and Nagoya University, Japan
19 August 2011 (online)
In contrast to the results of reacting aldehydes, there have been a limited number of examples that demonstrate a chemoselective and highly asymmetric alkynylation of ketones. The authors report a Rh/Phebox-catalyzed alkynylation of α-keto esters. A variety of alkynes are utilized in generally good yields with good to excellent enantioselectivities.