Copper(I)-Catalyzed α-Selective Allylic Alkylation

doi:10.1055/s-0030-1260877

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Synfacts 2011(9): 1009-1009
DOI: 10.1055/s-0030-1260877

Metal-Mediated Synthesis

Copper(I)-Catalyzed α-Selective Allylic Alkylation

Contributor(s): Paul Knochel, Thomas Kunz
A. M. Lauer, F. Mahmud, J. Wu*
Dartmouth College, Hanover, USA

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Publikationsdatum:
19. August 2011 (online)

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Significance

The authors report a novel copper(I)-catalyzed allylic alkylation reaction between phosphorothioate esters and organomagnesium reagents. This reaction shows excellent α-selectivity regardless of the Grignard reagent, and the methodology has been extended to secondary allylic halide substrates.