Asymmetric Mo-Catalyzed Allylic Alkylation of Cyano Esters

doi:10.1055/s-0030-1260865

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Synfacts 2011(9): 0987-0987
DOI: 10.1055/s-0030-1260865

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Asymmetric Mo-Catalyzed Allylic Alkylation of Cyano Esters

Contributor(s): Hisashi Yamamoto, Jiajing Tan
B. M. Trost*, J. R. Miller, C. M. Hoffman, Jr.
Stanford University, USA

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Publikationsdatum:
19. August 2011 (online)

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Significance

The authors reported a highly stereoselective and regioselective molybdenum-catalyzed allylic alkylation of cyanoesters. Various highly functionalized branched cyanoesters bearing vicinal tertiary and quaternary stereogenic centers are obtained in excellent yield and chemoselectivity and in good to excellent diastereoselectivity and enantioselectivity.