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Synfacts 2011(9): 0983-0983  
DOI: 10.1055/s-0030-1260860
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Asymmetric Conjugate Addition with N-Sulfinyl Ligands

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
X. Feng, Y. Wang, B. Wei, J. Yang*, H. Du*
Institute of Chemistry, Chinese Academy of Scienes, Beijing and Beijing University of Chemical Technology, P. R. of China
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Publication History

Publication Date:
19 August 2011 (online)

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Significance

N-Sulfinyl-based ligands are widely used in organic synthesis; these ligands bind to metals through either nitrogen or oxygen. In this report, the authors use N-sulfinyl-based ligands to bind through sulfur, as proven by X-ray crystal structure analysis. Because chirality is at the sulfur atom a strong chiral environment is present, as shown through the high enantioselectivities reported.