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Synfacts 2011(7): 0738-0738
DOI: 10.1055/s-0030-1260643
DOI: 10.1055/s-0030-1260643
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Reductive Coupling of Cyclic Enones and Alkynes towards Cyclic Ketones
C.-H. Wei, S. Mannathan, C.-H. Cheng*
National Tsing Hua University, Hsinchu, Taiwan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. Juni 2011 (online)
Significance
The authors disclose a cobalt-catalyzed asymmetric reductive coupling of cyclic enones and alkynes to afford β-substituted cyclic ketones with moderate to good yields and generally good enantioselectivities. It is shown that five-, six-, and seven-membered enones all undergo reductive couplings with internal aromatic alkynes. The authors propose a possible reaction mechanism.