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Synfacts 2011(7): 0763-0763
DOI: 10.1055/s-0030-1260506
DOI: 10.1055/s-0030-1260506
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Rh-Catalyzed Asymmetric 1,4-Addition to Yield Flavanones
T. Korenaga*, K. Hayashi, Y. Akaki, R. Maenishi, T. Sakai*
Okayama University, Japan
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
An efficient method for the highly enantioselective synthesis of flavanones via rhodium-catalyzed asymmetric 1,4-addition of boronic acids to chromene derivatives is described. The reaction is achieved using the rhodium catalyst with highly electron-poor chiral diphosphine MeO-F12-BIPHEP as ligand.