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Synfacts 2011(7): 0775-0775  
DOI: 10.1055/s-0030-1260503
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Carboamination Reactions to Yield Saturated 1,4-Benzodiazepines

Contributor(s): Paul Knochel, Andreas K. Steib
J. D. Neukom, A. S. Aquino, J. P. Wolfe*
University of Michigan, Ann Arbor, USA
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

In this work, a new synthetic ­access to saturated 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones via palladium-catalyzed alkene carboaminations is described. Substrates bearing allylic methyl groups are transformed to cis-2,3-disubstituted products with a diastereomeric ratio larger than 20:1.