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Synfacts 2011(7): 0770-0770  
DOI: 10.1055/s-0030-1260500
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Sequential Aldol Condensation-Rhodium-Catalyzed Addition Reaction

Contributor(s): Paul Knochel, Andreas K. Steib
Y.-X. Liao, C.-H. Xing, M. Israel, Q.-S. Hu*
The City University of New York, Staten Island, USA
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Herein, a sequential aldol reaction of aldehydes with methyl ketones followed by rhodium- or palladium-catalyzed additions of arylboronic acids yielding β-substituted ketones is ­described. An asymmetric version of this reaction was achieved by using an optically active 1,1′-spirobiindane-7,7′-diol (SPINOL)-based phosphite ligand.