Synfacts 2011(7): 0771-0771  
DOI: 10.1055/s-0030-1260494
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Suzuki-Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates

Contributor(s): Paul Knochel, Thomas Kunz
K. W. Quasdorf, A. Antoft-Finch, P. Liu, A. L. Silberstein, A. Komaromi, T. Blackburn, S. D. Ramgren, K. N. Houk*, V. Snieckus*, N. K. Garg*
University of California, Los Angeles, USA and Queen’s University, Kingston, Canada
Further Information

Publication History

Publication Date:
17 June 2011 (online)

Significance

In this work, the first Suzuki-Miyaura cross-coupling of aryl carbamates and sulfamates is described. In this protocol, the inexpensive and stable nickel catalyst NiCl2(PCy3)2 is employed and allows the coupling of substrates with both electron-withdrawing and -donating groups. Numerous functional groups and ortho substituents are tolerated. Furthermore, hetero­cyclic compounds were successfully used for both coupling partners.