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Synfacts 2011(6): 0627-0627  
DOI: 10.1055/s-0030-1260431
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium-Catalyzed Asymmetric [2+2] Cycloaddition of Ynamides with Enones

Contributor(s): Hisashi Yamamoto, Patrick Brady
C. Schotes, A. Mezzetti*
ETH Zürich, Switzerland
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Publication History

Publication Date:
19 May 2011 (online)

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Significance

The chiral dicationic ruthenium complex catalyzes the asymmetric [2+2] cyclo­addition of cyclic β-keto esters with ynamides. The reaction tolerates a wide range of substrates and generates an all-carbon quaternary stereogenic center in high yield and with high asymmetric induction.