Syntheses of Guanacastepenes N and O

doi:10.1055/s-0030-1260370

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Synfacts 2011(6): 0591-0591
DOI: 10.1055/s-0030-1260370

Synthesis of Natural Products and Potential Drugs

Syntheses of Guanacastepenes N and O

Contributor(s): Steven V. Ley, Sean Newton
C. M. Gampe, E. M. Carreira*
ETH Zürich, Switzerland

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Publication History

Publication Date:
19 May 2011 (online)

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Significance

Guanacastepenes N and O belong to a family of diterpenes, isolated in 2001. They exhibit antibiotic activity and consist of an unprecedented tricyclic carbon skeleton and five stereogenic centers. Guanacastepenes N and O are epimeric at C13.