Abstract
In this Account, recent advances in the total synthesis of complex
molecular architectures originating from the author’s laboratory
are highlighted and discussed. Through thoughtful planning, intelligence
gathering, and often serendipitous discoveries, a diverse collection
of natural products spanning several structural classes have been
successfully synthesized. The valuable information garnered from
these synthetic campaigns showcases the unparalleled and undisputed
value of this historical discipline and its cemented role in advancing
synthetic organic chemistry to new heights and horizons.
1 Introduction
2 Total Synthesis of the Thiopeptide Antibiotics
3 Total Synthesis of the Cytotoxic Marine Macrolide, Palmerolide
A
4 Total Synthesis of the Fab-Inhibitory Antibiotics, Platensimycin
and Platencin
5 Total Synthesis of the Antiangiogenic Agents, the Cortistatins
6 Total Synthesis of the Resveratrol-Derived Bioactive Polyphenols,
Hopeanol and Hopeahainol A
7 Total Synthesis of the Dimeric Bis-indole Alkaloid, Haplophytine
8 Total Synthesis of the Novel Sesquiterpenoids, Echinopine
A and B
9 Total Synthesis of the Selective Cytotoxic Agent towards Renal
Cancer Cells, Englerin A
10 Formal Synthesis of the Furanobis-indole Alkaloid, Phalarine
11 Total Synthesis of the Neuroprotective Agent, Nanolobatolide
12 Conclusion
Key words
natural products - total synthesis - biomimetic
synthesis - stereoselective synthesis - chiral pool
