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Synfacts 2011(5): 0511-0511  
DOI: 10.1055/s-0030-1259871
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Asymmetric Synthesis of Axially Chiral Diphosphine Ligands

Contributor(s): Hisashi Yamamoto, Zhi Li
F. Mori, N. Fukawa, K. Noguchi, K. Tanaka*
Tokyo University of Agriculture and Technology, Japan
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Publikationsdatum:
15. April 2011 (online)

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Significance

Axially chiral phosphine ligands have been widely used in numerous metal-­catalyzed asymmetric syntheses since its discovery. In this report an improved rhodium-catalyzed [2+2+2] cycloaddition is developed to enable the enantioselective synthesis of a chiral bis-phosphine ligand with higher steric demand directly from its poly-yne precursor.