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Synfacts 2011(5): 0463-0463  
DOI: 10.1055/s-0030-1259793
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Strychnine

Contributor(s): Steven V. Ley, Philippa B. Cranwell
D. B. C. Martin, C. D. Vanderwal*
University of California, Irvine, USA
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Publikationsdatum:
15. April 2011 (online)

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Significance

Strychnine is a highly toxic alkaloid isolated from seeds of the Strychnos nux vomica tree. It was first synthesized by Woodward and co-workers in 1954, and has since proved a popular target within the synthetic community. This approach is highly efficient and only requires six steps in the longest ­linear sequence.