Synfacts 2011(5): 0465-0465  
DOI: 10.1055/s-0030-1259792
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Diazonamide A

Contributor(s): Steven V. Ley, Philippa B. Cranwell
R. R. Knowles, J. Carpenter, S. B. Blakey, A. Kayano, I. K. Mangion, C. J. Sinz, D. W. C. MacMillan*
Princeton University, USA
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Publikationsverlauf

Publikationsdatum:
15. April 2011 (online)

Significance

Diazonamide A, a popular synthetic target, was isolated from the colonial marine asci­dian Diazonia angulata. It is a potent antimitotic agent and exhibits nanomolar GI50 values towards a range of human cancer cell lines.