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Synfacts 2011(5): 0469-0469  
DOI: 10.1055/s-0030-1259789
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Oxocrinine and Formal Synthesis of (±)-Crinine

Contributor(s): Steven V. Ley, James R. Frost
L. Yang, X. Wang, Z. Pan, M. Zhou, W. Chen, X. Yang*
Yunnan University of Nationalities and Yunnan University, Kunming, P. R. of China
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Publikationsdatum:
15. April 2011 (online)

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Significance

(±)-Oxocrinine and (±)-crinine are both structurally unique amaryllidaceae-type alkaloids. This particular subclass of natural products has shown antimalarial, immunostimulatory, cytotoxic and anticholinergic activity.