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Synfacts 2011(5): 0547-0547
DOI: 10.1055/s-0030-1259780
DOI: 10.1055/s-0030-1259780
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Activation of Vinyl Iodides for the Highly Enantioselective Addition to Aldehydes
A. M. DeBerardinis, M. Turlington, L. Pu*
University of Virginia, Charlottesville, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
15. April 2011 (online)
Significance
The authors report a highly enantioselective organocatalyst based on octahydro-BINOL for the reaction of various vinyl iodides with a range of aliphatic and aromatic aldehydes via an iodine-zinc exchange using diethylzinc. Substituted and functionalized allylic alcohols can be obtained in high enantiomeric purity under mild reaction conditions.