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Synfacts 2011(5): 0466-0466  
DOI: 10.1055/s-0030-1259766
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Kynurenine 3-Hydroxylase Inhibitor FCE28833

Contributor(s): Philip Kocienski
T. Jousseaume, N. E. Wurz, F. Glorius*
Universität Münster, Germany
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Publication History

Publication Date:
15 April 2011 (online)

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Significance

FCE28833 inhibits kynurenine 3-hydroxylase thereby elevating levels of kynurenic acid, an endogenous excitatory amino acid receptor antagonist. It may have therapeutic value in treating diseases linked to hyperfunction of excitatory amino acid receptors. A short and highly enantioselective synthesis of FCE28833 features an asymmetric intermolecular Stetter reaction catalyzed by the N-heterocyclic carbene E.