Copper-Catalyzed Oxidative Trifluoromethylation of Boronic Acids

Significance

A copper-catalyzed oxidative cross-coupling of readily available aryl- and alkenylboronic acids with (trifluoromethyl)trimethyl­silane is reported. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. Thus, the introduction of tri­fluoromethyl groups in advanced and highly ­functionalized compounds can be achieved at a late synthetic step.