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Synfacts 2010(11): 1275-1275  
DOI: 10.1055/s-0030-1258807
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Conjugate Addition of Arylboronic Acids to Nitroolefins

Contributor(s): Hisashi Yamamoto, Patrick Brady
Z.-Q. Wang, C.-G. Feng, S.-S. Zhang, M.-H. Xu*, G.-Q. Lin*
Shanghai Institute of Organic Chemistry and Shanghai Institute of Materia Medica, P. R. of China
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Publication Date:
21 October 2010 (online)

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Significance

This report describes conjugate ­addition to nitroolefins with high yields and good to excellent enantioselectivities. This method overcomes the previously described difficulties in controlling enantioselectivity for substrates lacking α-substituents.