Pd-Catalyzed Asymmetric Cross-Coupling of Allyl Carbonates and Allyl Boronates

Significance

The authors describe here a high-yielding, highly regio- and enantioselective cross-coupling of allyl carbonates and allyl boro­nates. Remarkably, nearly identical results are obtained for regioisomers 1 and 2. Importantly, aromatic and aliphatic allyl carbonates are tolerated under the reaction conditions. Allyl-allyl coupling in high regio- and stereoselectivity is a long-standing challenge in organic synthesis and this method provides an excellent solution.