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Synfacts 2010(11): 1217-1217  
DOI: 10.1055/s-0030-1258717
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Norsecurinine

Contributor(s): Steven V. Ley, Sean Newton
M. R. Medeiros, J. L. Wood*
Yale University, New Haven and Colorado State University, Fort Collins, USA
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

(+)-Norsecurinine belongs to the Securinega alkaloid series isolated from the plant family Euphorbiaceae. These compounds exhibit a broad spectrum of biological activities and contain synthetically challenging indolizidine or pyrrolizidine motifs. An enantioselective synthesis of (+)-norsecurinine is described.