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Synfacts 2010(10): 1143-1143  
DOI: 10.1055/s-0030-1258689
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iron-Catalyzed Asymmetric OH Bond Insertions

Contributor(s): Hisashi Yamamoto, Zhi Li
S.-F. Zhu, Y. Cai, H.-X. Mao, J.-H. Xie, Q.-L. Zhou*
Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

The authors developed a highly efficient iron-catalyzed protocol for the enantioselective carbene OH insertion. The reaction produces various α-alkoxy and α-hydroxyl arylacetates, which are quite useful synthetic intermediates, in very high yield and enantioselectivities.