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Synfacts 2010(10): 1208-1208  
DOI: 10.1055/s-0030-1258664
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Regioselective Ring Opening of Epoxides with [Fe(BTC)]

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
A. Dhakshinamoorthy, M. Alvaro, H. Garcia*
Universidad Politécnica de Valencia, Spain
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

An iron-based metal-organic framework [Fe(BTC)] (BTC = 1,3,5-benzenetri­carboxylate) catalyzed the ring opening of epoxides 1 with alcohols 2 or amines 3 to give the corresponding alcohols 4 in up to 93% GC yield (16 ­examples). In the reaction of styrene oxide with methanol, the catalyst was recovered by decantation and reused three times without significant loss of its catalytic activity (3rd reuse: 98% conversion). After the reaction, XRPD analysis revealed no change of the crystal structure of the catalyst.