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Synfacts 2010(10): 1204-1204  
DOI: 10.1055/s-0030-1258660
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Continuous Flow C-H Borylation of Arenes

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
T. Tagata, M. Nishida, A. Nishida*
Chiba University and Koei Chemical Company, Chiba, Japan
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

The iridium complex catalyst, ­BPDCA-cat, was prepared from chloro(1,5-cyclo-octadiene)iridium(I) dimer and 2,2′-bipyridine-4,4′-dicarboxylic acid in the presence of bis(pinacolato)diboron (1) in benzene. BPDCA-cat was applied to C-H borylation under flow system. Thus, a solution of aromatic substrates and 1 was installed into the stainless column reactor (4 mm x 30 mm) charged with BPDCA-cat (145 mg) under flow conditions (0.1 mmol/h) using a syringe pump to give the corresponding borylated products 2 in 67-93% yield.