Download PDF
Synfacts 2010(10): 1154-1154  
DOI: 10.1055/s-0030-1258651
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Regio- and Stereoselective Three-Component Reaction towards 1,3-Dienes

Contributor(s): Mark Lautens, Norman Nicolaus
C.-M. Yang, M. Jeganmohan, K. Parthasarathy, C.-H. Cheng*
National Tsing Hua University, Hsinchu, Taiwan
Further Information

Publication History

Publication Date:
22 September 2010 (online)

    Permissions and Reprints

Significance

Multicomponent reactions can be efficiently used to build complex organic molecules from simple starting materials. A new nickel-catalyzed three-component coupling of alkynes, enones, and alkenyl boronic acids is described. The methodology allows the formation of 1,3-dienes in good to excellent yields and in a regio- and stereoselective fashion. Furthermore, the reaction works smoothly with acetylene gas as simple C2-building block.