Diastereoselective Catalytic C-H Amination

Significance

The metal-mediated direct amination through C-H bond insertion is a very powerful transformation. It usually requires a metal nitrene species which undergoes C-H insertion into the most nucleophilic C-H bond. Herein, the authors report their preliminary results of a diastereoselective version of this reaction applied to acyclic substrates of type 1, proceeding with an excellent degree of selectivity and high yields.