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Synfacts 2010(11): 1271-1271
DOI: 10.1055/s-0030-1258590
DOI: 10.1055/s-0030-1258590
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Alkynylation of Nitroalkenes
T. Nishimura*, T. Sawano, S. Tokuji, T. Hayashi*
Kyoto University, Japan
Further Information
Publication History
Publication Date:
21 October 2010 (online)
Significance
The authors report on the rhodium-catalyzed alkynylation of nitroalkenes. Previously, alkynylzinc reagents were reported to undergo conjugate addition to nitroalkenes in the presence of a stoichiometric amount of a chiral amino alcohol (M. Yamashita, K. Yamada, K. Tomioka Org. Lett. 2005, 7, 2369). Thus, this report represents a significant improvement in terms of atom economy and provides an efficient route to chiral homopropargyl amines.