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Synfacts 2010(8): 0955-0955
DOI: 10.1055/s-0030-1257811
DOI: 10.1055/s-0030-1257811
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Michael Reaction of α,α-Disubstituted Aldehydes and Maleimides
F. Xue, L. Lu, S. Zhang, W. Duan*, W. Wang*
University of New Mexico, Albuquerque, USA; East China University of Science, Shanghai and Shanghai Institute of Materia Medica, P. R. of China
Further Information
Publication History
Publication Date:
22 July 2010 (online)
Significance
An enantioselective Michael reaction of α,α-disubstituted aldehydes and maleimides has been reported. The biologically useful chiral disubstituted α-branched succinimides 1 were obtained in good yields and high enantioselectivities under mild reaction conditions.