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DOI: 10.1055/s-0030-1256644
© Georg Thieme Verlag KG Stuttgart · New York
Pancreatic cystic neoplasm presenting as a large gastric ulcer
Publication History
Publication Date:
08 November 2011 (online)

An 85-year-old woman was admitted with painless obstructive jaundice that had developed over the previous few weeks. Ultrasound examination showed intrahepatic and extrahepatic duct dilatation; the common bile duct (CBD) measured 2.5 cm, and there was a suggestion of pancreatic duct dilatation. A few gallstones were identified in an otherwise normal-looking gallbladder, but no obstructing CBD stones were seen. The dilated biliary system was confirmed by endoscopic retrograde cholangiopancreatography (ERCP); no stones were identified in the CBD, but a copious amount of mucus was cleared from the duct. A large gastric ulcer was also noted at ERCP, which was confirmed on formal gastroduodenoscopy and was also seen to be secreting thick mucus into the stomach ([Fig. 1]).
Fig. 1 Esophagogastroduodenoscopy showing a large, mucus-secreting gastric ulcer.
A computed tomography (CT) scan showed a cystic pancreatic mass, and on magnetic resonance cholangiopancreatography (MRCP) the dilated pancreatic duct was seen to form a connection to the stomach ([Fig. 2]).
Fig. 2 Magnetic resonance cholangiopancreatography (MRCP) showing: a the dilated pancreatic duct that had formed a fistula; b the stomach with the other end of the fistula.
Gastric ulcer biopsies showed fragments of a severely dysplastic villous tumour, but biliary brushings were inconclusive. An endoscopic ultrasound (EUS) with fine needle aspiration was performed, which confirmed the eventual diagnosis of a mucinous cystadenoma of the pancreas with a fistulating gastric metastasis.
There were extensive discussions with the patient and her daughter about further treatment options, but clinically she had become very frail, experiencing further bouts of cholangitis that required insertion of a metal stent, so the multidisciplinary decision was for palliative management.
Differentiation of pancreatic cysts between benign and malignant causes can be difficult, requiring a combination of clinical, radiological, and histological approaches [1]. The fistula seen in this case between the mucinous cystadenoma and the stomach wall represents a rare finding, not being a previously reported feature of pancreatic cystic neoplasms.
Endoscopy_UCTN_Code_CCL_1AB_2AD_3AC
References
- 1 Khalid A, Brugga W. ACG Practice guidelines for the diagnosis and management of neoplastic pancreatic cysts. Am J Gastroenterol. 2007; 102 2339-2349
S. MathewMD
Department of Gastroenterology
Croydon University
Hospital
Croydon
CR7 7YE
UK
Fax: +020-8401-3495
Email: sanjumathew@doctors.org.uk