This review reports the highlights of the first International Conference on Capsule
and Double-Balloon Endoscopy, held in Paris (27 – 28 August 2010), under the chairmanship
of Professor G. Gay (Nancy, France). The conference was devoted to the technical issues
and clinical experience related to capsule endoscopy and double-balloon endoscopy
(DBE), techniques that have been developed over the past decade for the endoscopic
investigation of intestinal diseases. The conference focused on the technical advances
of new-generation endoscopes and capsules and the clinical experience gained with
capsule endoscopy and DBE. Important advances in the knowledge of obscure gastrointestinal
bleeding, inflammatory bowel diseases, and celiac disease were also discussed. The
second part of the conference was mainly devoted to the investigation of the colon
and discussed the technical issues and results of initial controlled studies of the
colonic capsule vs. conventional colonoscopy. In addition, the clinical usefulness
of double colonoscopy was demonstrated in patients with previously failed colonoscopy.
Finally, the role of DBE was discussed with respect to the investigation and treatment
of patients with surgically modified anatomy. The conference was attended by 750 delegates
and presented a unique opportunity for an in-depth review of the current knowledge
in the field and to ascertain/determine the main lines for the future developments
of capsule endoscopy and DBE.
References
- 1
Cave D R, Fleischer D E, Leighton J A et al.
A multicenter randomized comparison of the Endocapsule and the Pillcam SB.
Gastrointest Endosc.
2008;
68
487-494
- 2
Hartmann D, Eickhoff A, Damian U, Riemann J F.
Diagnosis of small-bowel pathology using paired capsule endoscopy with two different
devices: a randomized study.
Endoscopy.
2007;
39
1041-1045
- 3
Pioche M, Gaudin J L, Edery J et al.
Comparaison de la rentabilité diagnostique des systèmes de vidéocapsule endoscopique
Given Pilcam SB2 et Intromedics Mirocam dans l’exploration des saignements digestifs
inexpliqués: étude multicentrique randomisée sur 78 patients [abstract].
Endoscopy.
2010;
42
A26
- 4
Eliakim R.
Video capsule endoscopy of the small bowel.
Curr Opin Gastroenterol.
2010;
26
129-133
- 5
Spada C, Riccioni M E, Costamagna G.
Rapid Access Real-Time device and Rapid Access software: new tools in the armamentarium
of capsule endoscopy.
Expert Rev Med Devices.
2007;
4
431-435
- 6
Fedeli P, Gasbarrini A, Cammarota G.
Spectral endoscopic imaging: the multiband system for enhancing the endoscopic surface
visualization.
J Clin Gastroenterol.
2011;
45
6-15
- 7
Pohl J, Aschmoneit I, Schuhmann S, Ell C.
Computed image modification for enhancement of small-bowel surface structures at video
capsule endoscopy.
Endoscopy.
2010;
42
490-492
- 8
Rondonotti E, Soncini M, Girelli C et al.
on behalf of AIGO, SIED and SIGE Lombardia. Small bowel capsule endoscopy in clinical
practice: a multicenter 7-year survey.
Eur J Gastroenterol Hepatol.
2010;
22
1380-1386
- 9
Ladas S D, Triantafyllou K, Spada C et al.
ESGE Clinical Guidelines Committee. European Society of Gastrointestinal Endoscopy
(ESGE): recommendations (2009) on clinical use of video capsule endoscopy to investigate
small bowel, oesophageal and colonic diseases.
Endoscopy.
2010;
42
220-227
- 10
American Gastroenterological Association .
Medical position statement: evaluation and management of occult and obscure gastrointestinal
bleeding.
Gastroenterology.
2000;
118
197-200
- 11
Annibale B, Capurso G, Baccini F et al.
Role of small bowel investigation in iron deficiency anaemia after negative endoscopic/histologic
evaluation of the upper and lower gastrointestinal tract.
Dig Liver Dis.
2003;
35
784-787
- 12
Delvaux M, Frederic M, Fassler I, Gay G.
Are patients with chronic iron-deficiency anaemia different from those with occult
gastrointestinal bleeding? Clinical characteristics and diagnostic yield of capsule
endoscopy (abstract).
Gastroenterology.
2008;
134
A676
- 13
Sheibani S, Levesque B G, Friedland S et al.
Long-term impact of capsule endoscopy in patients referred for iron-deficiency anemia.
Dig Dis Sci.
2010;
55
703-708
- 14
Bailey A A, Debinski H S, Appleyard M N et al.
Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three-center
Australian experience.
Am J Gastroenterol.
2006;
101
2237-2243
- 15
Delvaux M, Laurent V, Klopp I et al.
Intestinal tumors frequently revealed by an obscure and digestive bleeding (ODB) and
more easily diagnosed by capsule endoscopy (VCE) (abstract).
Gastrointest Endosc.
2005;
61
162
- 16
Gupta A, Postgate A J, Burling D et al.
A prospective study of MR enterography versus capsule endoscopy for the surveillance
of adult patients with Peutz-Jeghers syndrome.
Am J Roentgenol.
2010;
195
108-116
- 17
Tukey M, Pleskow D, Legnani P et al.
The utility of capsule endoscopy in patients with suspected Crohn’s disease.
Am J Gastroenterol.
2009;
104
2734-2739
- 18
Dionisio P M, Gurudu S R, Leighton J A et al.
Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected
and established small-bowel Crohn’s disease: a meta-analysis.
Am J Gastroenterol.
2010;
105
1240-1248
- 19
Triester S L, Leighton J A, Leontiadis G I et al.
A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities
in patients with non-stricturing small bowel Crohn’s disease.
Am J Gastroenterol.
2006;
101
954-964
- 20
Bourreille A, Ignjatovic A, Aabakken L et al.
World Organisation of Digestive Endoscopy (OMED) and the European Crohn’s and Colitis
Organisation (ECCO). Role of small-bowel endoscopy in the management of patients with
inflammatory bowel disease: an international OMED-ECCO consensus.
Endoscopy.
2009;
41
618-637
- 21
Pons Beltrán V, Nos P, Bastida G et al.
Evaluation of postsurgical recurrence in Crohn’s disease: a new indication for capsule
endoscopy?.
Gastrointest Endosc.
2007;
66
533-540
- 22
Barratt H S, Kalantzis C, Polymeros D, Forbes A.
Functional symptoms in inflammatory bowel disease and their potential influence in
misclassification of clinical status.
Aliment Pharmacol Ther.
2005;
21
141-147
- 23
Lewis B S.
Expanding role of capsule endoscopy in inflammatory bowel disease.
World J Gastroenterol.
2008;
14
4137-4141
- 24
Gal E, Geller A, Fraser G et al.
Assessment and validation of the new capsule endoscopy Crohn’s disease activity index
(CECDAI).
Dig Dis Sci.
2008;
53
1933-1937
- 25
Lorenzo-Zúñiga V, de Vega V M, Domènech E et al.
Impact of capsule endoscopy findings in the management of Crohn’s Disease.
Dig Dis Sci.
2010;
55
411-414
- 26
Cellier C, Green P H, Collin P, Murray J.
ICCE consensus for celiac disease.
Endoscopy.
2005;
37
1055-1059
- 27
Ciaccio E J, Bhagat G, Tennyson C A et al.
Quantitative assessment of endoscopic images for degree of villous atrophy in celiac
disease.
Dig Dis Sci.
2010;
Sep 16
[Epub ahead of print]
- 28
Eliakim R, Fireman Z, Gralnek I M et al.
Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results
of the first multicenter, prospective, comparative study.
Endoscopy.
2006;
38
963-970
- 29
Schoofs N, Devière J, Van Gossum A.
PillCam colon capsule endoscopy compared with colonoscopy for colorectal tumor diagnosis:
a prospective pilot study.
Endoscopy.
2006;
38
971-977
- 30
Devière J, Munoz-Navas M A, Fernandez-Urien I et al.
PillCam Colon capsule endoscopy compared to colonoscopy in detection of colon polyps
and cancers.
N Engl J Med.
2009;
361
264-270
- 31
Gay G, Delvaux M, Frederic M, Fassler I.
Could the colonic capsule PillCam Colon be clinically useful for selecting patients
who deserve a complete colonoscopy? Results of clinical comparison with colonoscopy
in the perspective of colorectal cancer screening.
Am J Gastroenterol.
2010;
105
1076-1086
- 32
Sacher-Huvelin S, Coron E, Gaudric M et al.
Colon capsule endoscopy vs. colonoscopy in patients at average or increased risk of
colorectal cancer.
Aliment Pharmacol Ther.
2010;
32
1145-1153
- 33
Eliakim R, Yassin K, Niv Y et al.
Prospective multicenter performance evaluation of the second-generation colon capsule
compared with colonoscopy.
Endoscopy.
2009;
41
1026-1031
- 34
Spada C, Hassan C, Marmo R et al.
Meta-analysis shows colon capsule endoscopy is effective in detecting colorectal polyps.
Clin Gastroenterol Hepatol.
2010;
8
516-522
- 35
Spada C, Hassan C, Sturniolo G C et al.
Literature review and recommendations for clinical application of Colon Capsule Endoscopy.
Dig Liver Dis.
2010;
Nov 8
DOI: 10.1016/j.dld.2010.10.001
- 36
Triantafyllou K, Papanikolaou I S, Papaxoinis K et al.
Two cameras detect more lesions in the small bowel than one. Final results of a small
bowel capsule endoscopy feasibility trial with PillCam Colon (abstract).
Endoscopy.
2009;
41 Suppl. 1
A39
- 37
Yamamoto H, Sekine Y, Sato Y et al.
Total enteroscopy with a non-surgical steerable double-balloon method.
Gastrointest Endosc.
2001;
53
216-220
- 38
May A, Nachbar L, Wardak A et al.
Double-balloon enteroscopy: preliminary experience in patients with obscure gastrointestinal
bleeding or chronic abdominal pain.
Endoscopy.
2003;
35
985-991
- 39
Kawamura T, Yasuda K, Tanaka K et al.
Clinical evaluation of a newly developed single-balloon enteroscope.
Gastrointest Endosc.
2008;
68
1112-1116
- 40
May A, Färber M, Aschmoneit I et al.
Prospective multicenter trial comparing push-and-pull enteroscopy with the single-
and double-balloon techniques in patients with small-bowel disorders.
Am J Gastroenterol.
2010;
105
575-581
- 41
Akerman P A, Agrawal D, Chen W et al.
Spiral enteroscopy: a novel method of enteroscopy by using the Endo-Ease Discovery
SB overtube and a pediatric colonoscope.
Gastrointest Endosc.
2009;
69
327-332
- 42
Frieling T, Heise J, Sassenrath W et al.
Prospective comparison between double-balloon enteroscopy and spiral enteroscopy.
Endoscopy.
2010;
42
885-888
- 43
Witkin A S, Fenkel J M, Infantolino A, Conn M.
Spiral enteroscopy in geriatric patients: retrospective review of a single-center
experience (abstract).
Gastrointest Endosc.
2010;
71
AB371
- 44
Judah J R, Draganov P V, Lam Y et al.
Spiral enteroscopy is safe and effective for an elderly United States population of
patients with numerous comorbidities.
Clin Gastroenterol Hepatol.
2010;
8
572-576
- 45
Gay G, Delvaux M, Fassler I.
Outcome of capsule endoscopy in determining indication and route for push-and-pull
enteroscopy.
Endoscopy.
2006;
38
49-58
- 46
Pasha S F, Leighton J A.
How useful is capsule endoscopy for the selection of patients for double-balloon enteroscopy?.
Nat Clin Pract Gastroenterol Hepatol.
2008;
5
490-491
- 47
Shinozaki S, Yamamoto H, Yano T et al.
Long-term outcome of patients with obscure gastrointestinal bleeding investigated
by double-balloon endoscopy.
Clin Gastroenterol Hepatol.
2010;
8
151-158
- 48
Mönkemüller K, Fry L C, Meyer F et al.
Midgut bleeding: the concept of emergency double balloon enteroscopy (DBE) (abstract).
Gastrointest Endosc.
2009;
69
AB199
- 49
Ell C, May A.
Mid-gastrointestinal bleeding: capsule endoscopy and push-and-pull enteroscopy give
rise to a new medical term.
Endoscopy.
2006;
38
73-75
- 50
Okazaki H, Fujiwara Y, Sugimori S et al.
Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal
bleeding: multi-center experience with 1,044 consecutive patients.
J Gastroenterol.
2009;
44
550-555
- 51
Sunada K, Yamamoto H, Kita H et al.
Clinical outcomes of enteroscopy using the double-balloon method for strictures of
the small intestine.
World J Gastroenterol.
2005;
11
1087-1089
- 52
Rex D K, Bond J H, Winawer S U.S. Multi-Society Task Force on Colorectal Cancer et
al..
Quality in the technical performance of colonoscopy and the continuous quality improvement
process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal
Cancer.
Am J Gastroenterol.
2002;
97
1296-1308
- 53
Gay G, Delvaux M.
Double-balloon colonoscopy after failed conventional colonoscopy: a pilot series with
a new instrument.
Endoscopy.
2007;
39
788-792
- 54
Pasha S F, Harrison M E, Das A et al.
Utility of double-balloon colonoscopy for completion of colon examination after incomplete
colonoscopy with conventional colonoscope.
Gastrointest Endosc.
2007;
65
848-853
- 55
May A, Nachbar L, Ell C.
Push-and-pull enteroscopy using a single-balloon technique for difficult colonoscopy.
Endoscopy.
2006;
38
395-398
- 56
Haidouri O, Delvaux M, Frederic M et al.
Double balloon colonoscopy in patients with previous difficult and incomplete colonoscopy:
rate of caecal intubation and diagnostic yield [abstract].
Endoscopy.
2010;
42 Suppl I
A151
- 57
Shimatani M, Matsushita M, Takaoka M et al.
Effective “short” double-balloon enteroscope for diagnostic and therapeutic ERCP in
patients with altered gastrointestinal anatomy: a large case series.
Endoscopy.
2009;
41
849-854
M. DelvauxMD
Internal Medicine and Digestive Pathology
CHU de Nancy
Allee du Morvan
Vandoeuvre les Nancy 54511
France
Fax: +33-3-83154012
eMail: delvaux.mm@free.fr
