Endoscopy 2010; 42: E348-E349
DOI: 10.1055/s-0030-1255982
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Fibrin glue as a protective biomembrane for a duodenal ulcer vessel

G.  Germanidis1 , T.  S.  Papavramidis2 , K.  Mantzoukis1 , K.  Sapalidis2 , D.  Divanis1 , I.  Kalevrosoglou1 , E.  Chassapopoulou1 , P.  Nikolaidis1
  • 11st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • 23rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
Further Information

Publication History

Publication Date:
17 December 2010 (online)

Bleeding peptic ulcers are a common emergency, and contemporary endoscopic treatments include injection, thermal, and mechanical therapy [1]. We describe the use of fibrin glue as a protective biomembrane over a large, recently bleeding visible duodenal ulcer vessel and crater, at risk of perforation.

A 44-year-old woman was admitted for hematemesis and hypovolemic shock. She had been receiving 100 mg acetylsalicylic acid daily, which was the likely causative agent. She had homozygous β-thalassaemia, hemosiderosis, hepatomegaly, viral hepatitis C, type 2 diabetes mellitus, chronic renal failure under peritoneal dialysis, cardiac insufficiency due to restrictive cardiomyopathy treated with pacemaker, and hypothyroidism. She had undergone splenectomy and had her gallbladder removed.

The patient was resuscitated and emergency gastroscopy carried, out but it was impossible to identify bleeding vessels due to the excessive amount of bleeding and clots. After 12 hours a repeat gastroscopy identified a 2-cm FIIa-G ulcer on the posterior wall of the duodenal bulb; the crater base was formed almost entirely of muscle fibers ([Fig. 1]).

Fig. 1 Large ulceration in the posterior duodenal bulb wall with the crater base mainly consisting of muscle fibers. A 2 – 3-mm, nonbleeding but pulsing vessel is seen within the ulcer crater.

A large nonbleeding, but pulsing, vessel (diameter 2 – 3 mm) was observed in the crater of the ulcer. Any conventional measure to occlude the vessel was judged impossible, while an emergency operation was contraindicated. Fibrin glue as a bio-barrier was considered and 2 mL of the glue was applied on the crater through a double lumen catheter, in order to protect the exposed vessel from erosion ([Fig. 2]).

Fig. 2 The ulcer after initial fibrin glue application.

At 3 days, another gastroscopy revealed an intact, protective biofilm and an ongoing healing process. A further layer of fibrin glue was applied ([Fig. 3]).

Fig. 3 The ulcer after the second fibrin glue session.

After 1 month, a final gastroscopy was done to evaluate the stage of healing of the ulcer, which was noted to be adequate ([Fig. 4]), and the patient was thus discharged.

Fig. 4 Gastroscopy (1 month after the bleeding) showing healing of the ulcer.

Fibrin glue is used in fistulas, either alone or with endoclips [2] [3], because in addition to its mechanical role (occlusion), it has a role in wound healing [4]. The idea of using fibrin glue arose due to the very poor general condition of the patient and the fact that traditional endoscopic methods could lead to ulcer perforation. Fibrin glue seemed the ideal material to form a biomembrane (easily applied, impermeable to gastroduodenal fluids, enhanced wound healing).

The application of fibrin glue as a protective biomembrane over an exposed vessel in a duodenal ulcer was deemed successful in the present case. Of course, this technique has only been used in one patient and its overall effectiveness remains to be explored.

Competing interests: None



T. Papavramidis

3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki,

Aigaiou 6
54655 Thessaloniki

Email: papavramidis@hotmail.com