ABSTRACT
Esthesioneuroblastoma has a local recurrence rate of ~30%, but no standard regimen
for salvage of local recurrence has been established. We report data from 678 patients
from series published since 1990, with a risk reduction analysis of salvage with surgery,
radiation, or combined surgery and radiation therapy. We found a 28.5% rate of local
recurrence after treatment, and a 42.6% rate of successful salvage with surgery, radiation,
or combined treatment. The odds ratio for successful salvage, defined as disease-free
survival for at least 1 year, was not significantly different for combined surgery
and radiation versus surgery alone or radiation alone or for surgery alone versus
radiation alone. The salvage odds ratio for combined surgery and radiation therapy
versus radiation therapy alone, 3.5, approached, but did not reach statistical significance.
This study reveals a reasonable rate of successful salvage of local esthesioneuroblastoma
recurrence using surgery, radiation, or combined surgery and radiation.
KEYWORDS
Esthesioneuroblastoma - salvage - sinus - nasal cavity - olfactory neuroblastoma
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Adam M ZanationM.D.
Department of Otolaryngology, Head, and Neck Surgery
CB#7070, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599-7070
eMail: azanatio@med.unc.edu
