Skull Base 2011; 21(1): 001-006
DOI: 10.1055/s-0030-1254406
ORIGINAL ARTICLE

© Thieme Medical Publishers

Salvage Treatment of Local Recurrence in Esthesioneuroblastoma: A Meta-analysis

Mitchell R. Gore1 , Adam M. Zanation1
  • 1Department of Otolaryngology, Head, and Neck Surgery, University of North Carolina Hospitals, North Carolina
Further Information

Publication History

Publication Date:
23 June 2010 (online)

ABSTRACT

Esthesioneuroblastoma has a local recurrence rate of ~30%, but no standard regimen for salvage of local recurrence has been established. We report data from 678 patients from series published since 1990, with a risk reduction analysis of salvage with surgery, radiation, or combined surgery and radiation therapy. We found a 28.5% rate of local recurrence after treatment, and a 42.6% rate of successful salvage with surgery, radiation, or combined treatment. The odds ratio for successful salvage, defined as disease-free survival for at least 1 year, was not significantly different for combined surgery and radiation versus surgery alone or radiation alone or for surgery alone versus radiation alone. The salvage odds ratio for combined surgery and radiation therapy versus radiation therapy alone, 3.5, approached, but did not reach statistical significance. This study reveals a reasonable rate of successful salvage of local esthesioneuroblastoma recurrence using surgery, radiation, or combined surgery and radiation.

REFERENCES

Adam M Zanation, M.D. 

Department of Otolaryngology, Head, and Neck Surgery

CB#7070, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599-7070

Email: azanatio@med.unc.edu