Am J Perinatol 2010; 27(8): 619-624
DOI: 10.1055/s-0030-1249364
© Thieme Medical Publishers

Upper Respiratory Tract Infection during Pregnancy: Is It Associated with Adverse Perinatal Outcome?

Liran Stiller-Timor1 , Amalia Levy2 , Gershon Holcberg3 , Eyal Sheiner3
  • 1Otolaryngology Head & Neck Surgery Department, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel
  • 2Epidemiology and Health Services Evaluation, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel
  • 3Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel
Further Information

Publication History

Publication Date:
03 March 2010 (online)


We sought to determine whether there is an association between upper respiratory tract infection (URTI) requiring hospitalization during pregnancy and adverse perinatal complications. A retrospective population-based study comparing all singleton pregnancies of patients with and without URTI requiring hospitalization was performed. Multiple logistic regression models were performed to control for confounders. Data were collected from the computerized perinatal database. Out of 186,373 deliveries, 0.13% (n = 246) required hospitalization due to URTI during pregnancy. URTI was significantly associated with preterm deliveries (PTD; 15.9% versus 7.9%; p < 0.001), lower birth weight (3082 ± 624 versus 3183 ± 546 g; p < 0.001), and higher rate of cesarean deliveries (CD; 20.3% versus 13.2%; p < 0.001) as compared with the comparison group. Even after controlling for possible confounders using multivariable analyses, the significant association between URTI and PTD (weighted odds ratio [OR] = 2.2; 95% confidence interval [CI] 1.6 to 3.1; p < 0.001) and CD (weighted OR = 1.5; 95% CI 1.1 to 2.2; p = 0.020) persisted. In contrast, no significant association was documented between URTI and premature rapture of membranes (4.9% versus 6.9%; p = 0.212), low Apgar scores (< 7) at 5 minutes (0.4% versus 0.6%; p = 0.761), and perinatal mortality (0 to 4% versus 1.3%; p = 0.223). Maternal URTI requiring hospitalization is an independent risk factor for PTD and CD.


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Eyal SheinerM.D. Ph.D. 

Department of Obstetrics and Gynecology

Soroka University Medical Center, P.O. Box 151, Be'er-Sheva, Israel