Pharmacopsychiatry 2010; 43(3): 86-91
DOI: 10.1055/s-0029-1242817
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Effectiveness of Standardized Ginkgo biloba Extract on Cognitive Symptoms of Dementia with a Six-Month Treatment: A Bivariate Random Effect Meta-Analysis

B.-S. Wang1 [*] , H. Wang1 [*] , Y.-Y. Song1 , H. Qi1 , Z.-X. Rong1 , B.-S. Wang1 , L. Zhang2 , H.-Z. Chen1
  • 1Department of Pharmacology and Biostatistics, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China
  • 2Department of Biomedical Engineering, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China
Further Information

Publication History

received 26.02.2009 revised 28.08.2009

accepted 06.10.2009

Publication Date:
26 January 2010 (online)

Abstract

Introduction: The objective of this study is to take into consideration the influence of baseline risk on the treatment effect and evaluate the effectiveness of standardized Ginkgo biloba extract (GbE) on cognitive symptoms of dementia with the treatment period of approximately 6 months.

Methods: We systematically searched the literature to identify all randomized placebo-controlled clinical trials (English language) of GbE in the treatment of dementia. Data were extracted from selected trials and combined with standard meta-analysis methods. A bivariate meta-analysis was carried out to further estimate the effect size of GbE.

Results: The random effect estimate of standard mean difference (SMD) between GbE and placebo groups of 6 selected trials was −0.89 (95% CI −1.82 to 0.04) in the assessment of cognitive function. Bivariate random effect estimate of difference of change in ADAS-cog scores was −2.65 (95% CI –−4.53 to −0.76), which showed a significant difference in favor of GbE.

Conclusion: Considering baseline risk in the assessment of treatment effect, GbE was found to be effective for cognitive functions in dementia with the treatment of 6 months.

References

1 These authors contributed equally to this work.

Correspondence

H.-Z. Chen, PhD 

Department of Pharmacology and Biostatistics Shanghai

Jiaotong University School of Medicine

200025 Shanghai

People's Republic of China

Phone: +86/21/6467 4721

Fax: +86/21/6467 4721

Email: yaoli@shsmu.edu.cn

L. Zhang

Department of Biomedical Engineering

Shanghai Jiaotong University

School of Medicine

200025 Shanghai

People's Republic of China

Phone: +86/21/6384 6590

Fax: +86/21/5456 2380

Email: zhanglu614@126.com