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Synfacts 2010(6): 0668-0668  
DOI: 10.1055/s-0029-1219969
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Ullmann Coupling of Biaryl Dials Catalyzed by Nickel

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
W.-W. Chen, Q. Zhao, M.-H. Xu*, G.-Q. Lin*
Shanghai Institute of Organic Chemistry and Shanghai Institute of Materia Medica, P. R. of China
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Axially chiral biaryl moieties are common in natural products. The authors developed the first nickel-catalyzed asymmetric Ullmann coupling for substituted aryl halides to yield axially chiral biaryls, and applied this method to the formal synthesis of the natural product (+)-isoschizandrin.