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Synfacts 2010(6): 0726-0726  
DOI: 10.1055/s-0029-1219892
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted Carbonylation of Aryl Iodides with Pd/C

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
J. Salvadori, E. Balducci, S. Zaza, E. Petricci*, M. Taddei
Universitá degli Studi di Siena, Italy
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Carbonylation reactions of aryl ­iodides using the association of Pd/C and microwave dielectric heating were described. Microwave-assisted carbonylation of aryl iodides with alcohols or amines was carried out under CO in the presence of Pd/C and DBU to give the corresponding esters (20 to >99% yield, 16 examples) or amides (60-95% yield, 9 examples). Cyclo­carbonylation of o-iodoaniline with acyl chlorides or a hydroxysuccinimido derivative led to the corresponding benzoxazinones (45-82% yield, six examples) under similar conditions.