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Synfacts 2010(6): 0728-0728  
DOI: 10.1055/s-0029-1219889
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Claisen-Schmidt Condensation Catalyzed by MOF Composites

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
A. Dhakshinamoorthy, M. Alvaro, H. Garcia*
Universidad Politécnica de Valencia, Spain
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

A Claisen-Schmidt condensation was performed with a metal-organic famework 3 [Fe(BTC), BTC = 1,3,5-benzenetricarboxylic acid]. Thus, the condensation of acetophenone (1) and benzaldehyde (2) was carried out with Fe(BTC) 3 (145 mol% Fe) in toluene at 110 ˚C to give chalcone (4) in 98% yield. The catalyst 3 was recovered and reused three times with a gradual ­decrease in activity.