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Synfacts 2010(5): 0547-0547  
DOI: 10.1055/s-0029-1219673
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Hydrogenation of N-Protected Indoles Catalyzed by Iridium Complexes

Contributor(s): Hisashi Yamamoto, Zhi Li
A. Baeza, A. Pfaltz*
University of Basel, Switzerland
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Publikationsdatum:
22. April 2010 (online)

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Significance

In this work, several iridium complexes were developed to catalyze asymmetric hydrogenation of N-protected indoles which provided various indolines bearing C2 or C3 chirality in high yield and enantioselectivity. These catalysts were not only efficient but also practical in air and moisture stability.