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Synfacts 2010(5): 0579-0579  
DOI: 10.1055/s-0029-1219664
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Iron(II)-Catalyzed Radical Arylation of Arenes with Aryl and Heteroaryl Iodides

Contributor(s): Paul Knochel, Andrei Gavryushin
F. Vallée, J. J. Mousseau, A. B. Charette*
Université de Montréal, Canada
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Publication History

Publication Date:
22 April 2010 (online)

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Significance

Herein, the authors report a direct, high-yielding, mild, and versatile iron-catalyzed arylation of unactivated arenes with aryl and heteroaryl iodides. The iron catalyst is used in a low amount (5 mol%). The reaction does not require the presence of a directing group and is tolerant to the presence of functional groups in the substrates.