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Synfacts 2010(3): 0313-0313
DOI: 10.1055/s-0029-1219336
DOI: 10.1055/s-0029-1219336
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Enantioselective Friedel-Crafts Alkylation of Indoles
Y.-J. Sun, N. Li, Z.-B. Zheng, L. Liu, Y.-B. Yu, Z.-H. Qin, B. Fu*
China Agricultural University, Beijing, P. R. of China
Further Information
Publication History
Publication Date:
18 February 2010 (online)
Significance
Friedel-Crafts alkylation of indole derivatives with α,β-unsaturated carbonyl compounds has been extensively developed due to the importance of indoles as building blocks in natural products and pharmaceutical agents. Despite the many contributions already in the literature, challenges still remain in developing highly efficient chiral catalysts for the Friedel-Crafts alkylation between indole and alkylidenemalonate. The authors reported the studies of heteroarylidenemalonate-derived bis(oxazoline) ligands, such as 1, and their copper(II) complexes in the highly efficient and enantioselective Friedel-Crafts alkylation of indoles and alkylidenemalonates.