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Synfacts 2010(3): 0320-0320  
DOI: 10.1055/s-0029-1219318
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Difunctionalization of Alkenes Catalyzed by Palladium(II)

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
K. H. Jensen, T. P. Pathak, Y. Zhang, M. S. Sigman*
University of Utah, Salt Lake City, USA
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

The authors have developed a ­palladium-catalyzed difunctionalization of alkenes involving the addition of two distinct nucleophiles. The difunctionalized products were obtained in good yields, moderate to good diastereoselectivities and excellent enantioselectivities. It is noted that the scope of this methodology could be extended to carbon nucleophiles, affording the ­Diels-Alder products in good diastereoselectvities and excellent enantioselectivities.