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Synfacts 2010(3): 0336-0336
DOI: 10.1055/s-0029-1219314
DOI: 10.1055/s-0029-1219314
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Ruthenium Hydride Catalyzed Coupling of α,β-Unsaturated Aldehydes with Primary Alcohols
A. Denichoux, T. Fukuyama, T. Doi, J. Horiguchi, I. Ryu*
Osaka Prefecture University, Japan
Further Information
Publication History
Publication Date:
18 February 2010 (online)
Significance
A ruthenium hydride catalyzed cross-coupling between α,β-unsaturated aldehydes and primary alcohols was achieved. This atom-economical reaction leads to the formation of 2-hydroxymethyl ketones in 45-74% yield.