Synfacts 2010(3): 0336-0336  
DOI: 10.1055/s-0029-1219314
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium Hydride Catalyzed Coupling of α,β-Unsaturated Aldehydes with Primary Alcohols

Contributor(s): Paul Knochel, Tobias Thaler
A. Denichoux, T. Fukuyama, T. Doi, J. Horiguchi, I. Ryu*
Osaka Prefecture University, Japan
Further Information

Publication History

Publication Date:
18 February 2010 (online)

Significance

A ruthenium hydride catalyzed cross-coupling between α,β-unsaturated aldehydes and primary alcohols was achieved. This atom-economical reaction leads to the formation of 2-hydroxymethyl ketones in 45-74% yield.