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Synfacts 2010(2): 0182-0182
DOI: 10.1055/s-0029-1219214
DOI: 10.1055/s-0029-1219214
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Calcium-Catalyzed Enantioselective 1,4-Addition to Nitroalkenes
T. Tsubogo, Y. Yamashita, S. Kobayashi*
University of Tokyo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Januar 2010 (online)
Significance
The use of alkaline earth metals as catalysts offers numerous advantages over transition metals, such as low cost and toxicity. Extending their previous work on calcium catalysis (S. Kobayashi and co-workers J. Am. Chem. Soc. 2007, 129, 5364), the authors present an enantioselective 1,4-addition of malonates to nitroalkenes. Excellent yields and enantioselectivities are obtained.