A Novel Asymmetric Azaspirocyclisation Using a Morita-Baylis-Hillman-Type Reaction

Abstract

A Morita-Baylis-Hillman-type reaction has been applied to the asymmetric preparation of azaspirocycles in high yield and diastereoselectivity. The optimisation of the reaction is discussed and a model for the origin of diastereoselectivity is proposed.

Morita-Baylis-Hillman-type reaction - azaspirocyclisation - spiro compounds - asymmetric synthesis - diastereoselectivity

References and Notes

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