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Synfacts 2010(2): 0192-0192  
DOI: 10.1055/s-0029-1219142
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Catalyst System for Enantioselective Oxidative Cyclization

Contributor(s): Mark Lautens, David A. Candito
W. He, K.-T. Yip, N.-Y. Zhu, D. Yang*
The University of Hong Kong and The Fourth Military Medical University, Xi’an, P. R. of China
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

The Yang group has previously reported on the palladium(II)-catalyzed enantioselective oxidative cyclization of unsaturated anilides yielding indolines (J. Am. Chem. Soc. 2006, 128, 3130). In the present work they report a new catalyst system capable of providing excellent enantio- and diastereoselectivity. Furthermore, they put forth a transition-state model to predict the absolute configuration of the products.