Organocatalytic Double Michael Cascade Reactions
P. G. McGarraugh, S. E. Brenner*
Brooklyn College and the City University of New York, USA
21 January 2010 (online)
The authors report a secondary amine catalyzed Michael-Michael cascade reaction of α,β-unsaturated aldehydes with conjugated β-keto esters. The products were obtained in good yields and high stereoselectivities. The provided reaction mechanism is in accordance with the one usually reported for related reactions, representing an iminium-ion-enamine-iminium-ion cascade process.