Synfacts 2010(2): 0233-0233  
DOI: 10.1055/s-0029-1219132
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Organocatalytic Double Michael Cascade Reactions

Contributor(s): Benjamin List, Lars Ratjen
P. G. McGarraugh, S. E. Brenner*
Brooklyn College and the City University of New York, USA
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Publication History

Publication Date:
21 January 2010 (online)


The authors report a secondary amine catalyzed Michael-Michael cascade reaction of α,β-unsaturated aldehydes with conjugated β-keto esters. The products were obtained in good yields and high stereoselectivities. The provided reaction mechanism is in accordance with the one usually reported for related reactions, ­representing an iminium-ion-enamine-iminium-ion cascade process.